The primary outcome was the number of ventilator-free days from randomization until day Results: The number of ventilator-free days did not differ significantly between the conservative-oxygen group and the usual-oxygen group, with a median duration of The conservative-oxygen group spent more time in the ICU with an Fio 2 of 0. At days, mortality was Conclusions: In adults undergoing mechanical ventilation in the ICU, the use of conservative oxygen therapy, as compared with usual oxygen therapy, did not significantly affect the number of ventilator-free days.
However, the supporting evidence is limited, and there is concern about impaired organ perfusion. Methods: In a pragmatic, international trial, we randomly assigned patients who had an increased risk of complications while undergoing major abdominal surgery to receive a restrictive or liberal intravenous-fluid regimen during and up to 24 hours after surgery.
The primary outcome was disability-free survival at 1 year. Key secondary outcomes were acute kidney injury at 30 days, renal-replacement therapy at 90 days, and a composite of septic complications, surgical-site infection, or death. Results: During and up to 24 hours after surgery, patients in the restrictive fluid group had a median intravenous-fluid intake of 3.
The rate of disability-free survival at 1 year was
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